Viral infections and multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Role of early viral infections in development of multiple sclerosis.
INTRODUCTION Multiple sclerosis is a chronic inflammatory, autoimmune, demyelinating, disease but also degeneration of axons, with mainly progressive course, causing greater or lesser degree of disability. In addition to genetic predisposition the environmental factors, with particular importance of early viral infection, have an essential role in the development of MS. These are called long-ac...
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A controlled serologic survey of antibody titres to 17 viruses was undertaken in multiple sclerosis patients in the Orkney and Shetland Islands. No consistent pattern of elevated antibody titre levels or the presence of antibody was noted in patients compared with two control groups. Because of the isolation of these islands, the mean age at acquisition of common childhood infections, including...
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P HYSICIANS AND PATIENTS HAVE ALWAYS HAD A great fascination with the invisible pathogen. Koch’s criteria, set out as early as 1882, have generally been ignored, that is, a microorganism must be (1) present in every case of the disease and (2) isolated from the host with the disease and grown in pure culture, (3) the specific disease must be reproduced when a pure culture of the microbe is inoc...
متن کاملChildhood infections and risk of multiple sclerosis.
Multiple sclerosis has been hypothesized to be the result from an aberrant immune response possibly triggered by delayed exposure to a common childhood infection. Because the vast majority of previous studies testing this hypothesis have been based on a history of childhood infections recalled years to decades later in adulthood, we investigated whether age at six common childhood infections wa...
متن کاملComprehensive Viral Immunology of Multiple Sclerosis
0 EpldMldagkal, clinkal, and CSF data were collected on 87 patlenb wlth clinically definite multlple scleroris (MS) and 50 with probable MS. As part of a study of immundogk reactivity to vlral antigens, a control group separated into 26 patients with probable inflammatory neural disease and 140 with noninflammatory neural disease was similarly stub id. Among the groups with MS, females predomin...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Disease Models
سال: 2020
ISSN: 1740-6757
DOI: 10.1016/j.ddmod.2020.02.003